Related Experiment Video

Updated: Jul 15, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Rotavirus disease in young children from Hanoi, Vietnam

Ladaporn Bodhidatta1, Nguyen Thi Phong Lan, Bui Thu Hien

  • 1Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, Phyathai, Bangkok, Thailand. ladapornb@afrims.org

The Pediatric Infectious Disease Journal
|April 7, 2007
PubMed

Insights

Rotavirus was the primary cause of acute diarrhea in young children in Hanoi, Vietnam. This finding supports the use of the rotavirus vaccine to prevent diarrheal diseases in this age group.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Limited recent data exists on pathogen prevalence and antimicrobial resistance in Vietnamese children with diarrheal diseases.
  • This study aimed to fill this gap by investigating enteric pathogens in young children in Hanoi.

Purpose of the Study:

  • To determine the prevalence of enteric pathogens in children under 5 years old with acute diarrhea in Hanoi.
  • To assess antimicrobial susceptibility patterns of common bacterial enteropathogens.

Main Methods:

  • Prospective study involving 291 children with acute diarrhea and 291 age-matched controls.
  • Detection of enteric bacteria and viruses using standard culture methods and enzyme immunoassay.

Main Results:

  • Viral pathogens, particularly rotavirus (31% in cases), were the most common cause of diarrhea.
  • Bacterial pathogens like Aeromonas (15%) and Shigella (9%) were also identified.
  • Fluoroquinolone resistance was noted in 27% of Campylobacter isolates.

Conclusions:

  • Rotavirus is a significant etiological agent of acute diarrhea in children under 5 in Hanoi.
  • The high burden of rotavirus disease suggests the rotavirus vaccine should be considered for implementation.
Abstract

More Related Videos

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR15:16

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

Related Concept Videos

Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...