Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 15, 2026

Surgical Treatment of an Endolymphatic Sac Tumor

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

Neuroblastoma masquerading as cervical lymphadenitis.

Stephanie Pepper¹, Humayun K Islam, Somasundarm Jayabose

¹Department of Pediatrics, New York Medical College, Maria Fareri Children's Hospital, Valhalla, NY 10595, USA.

Journal of Pediatric Hematology/Oncology

|April 7, 2007

Summary

Pediatric cervical lymphadenitis, often infectious, can mask serious conditions like neuroblastoma. Histopathology revealed metastatic neuroblastoma in a young boy initially presenting with typical infectious lymphadenitis symptoms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Erratum: Efficiently targeting neuroblastoma with the combination of anti-ROR1 CAR NK cells and N-803 <i>in vitro</i> and <i>in vivo</i> in NB xenografts.

Molecular therapy. Oncology·2026

Same author

New Insights Into the Role of Polo-Like Kinase 3 in Lung Tumorigenesis.

Journal of cellular biochemistry·2026

Same author

Ferroptosis-The "Double-Edged Sword" in Cancer: Mechanisms of Tumor Suppression/Resistance and Therapeutic Manipulation.

Biology·2026

Same author

Long Non-Coding RNA DUXAP10 Promotes Tumorigenesis and Metastasis in Anaplastic Thyroid Cancer.

Cancers·2025

Same author

Myelin oligodendrocyte glycoprotein antibody-associated disease with aseptic meningitis-like presentation in a paediatric patient.

BMJ case reports·2025

Same author

Berberine Suppression of Human IgE but Not IgG Production via Inhibition of STAT6 Binding Activity at IgE Promoter by BCL6.

Cells·2025

Area of Science:

Pediatric oncology
Pathology
Infectious disease

Background:

Cervical lymphadenitis is a frequent pediatric condition requiring medical assessment.
Infectious and reactive causes are most common for cervical lymphadenitis.
Lymph node location can suggest the origin of pathology.

Observation:

A 21-month-old boy presented with symptoms mimicking infectious lymphadenitis.
The child was diagnosed with metastatic neuroblastoma.
The presentation was initially misleading, resembling a common infection.

Findings:

Metastatic neuroblastoma can present with clinical features indistinguishable from infectious lymphadenitis.
Surgical intervention and histopathological examination were crucial for diagnosis.

Related Experiment Videos

Last Updated: Jul 15, 2026

Surgical Treatment of an Endolymphatic Sac Tumor

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

The case highlights an unusual presentation of a pediatric malignancy.

Implications:

Clinicians should consider rare diagnoses in pediatric cervical lymphadenitis, even with typical infectious signs.
Early recognition of atypical presentations is vital for timely neuroblastoma diagnosis and treatment.
This case underscores the importance of thorough histopathological evaluation in pediatric lymphadenopathy.