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Two-dimensional biosensor arrays based on surface plasmon resonance phase imaging.

C L Wong1, H P Ho, T T Yu

  • 1Center for Advanced Research in Photonics, The Chinese University of Hong Kong, China.

Applied Optics
|April 7, 2007
PubMed
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We developed a novel two-dimensional (2D) phase imaging biosensor using surface plasmon resonance (SPR). This technology enables rapid, label-free detection of multiple analytes simultaneously on a microarray chip.

Area of Science:

  • Biosensing technologies
  • Optical physics
  • Surface chemistry

Background:

  • Surface Plasmon Resonance (SPR) is a label-free optical technique for detecting molecular interactions.
  • Conventional SPR systems often require angular scanning, limiting speed and parallelization.
  • There is a growing need for high-throughput, real-time biosensing for biomedical applications.

Purpose of the Study:

  • To present a novel biosensor design utilizing two-dimensional (2D) phase imaging of SPR.
  • To demonstrate the potential for parallel, label-free detection of multiple analytes.
  • To highlight the compatibility of the technique with microarray chip platforms.

Main Methods:

  • Utilizing a differential phase measurement approach by comparing 2D phase maps from signal (P) and reference (S) polarizations pixel by pixel.

Related Experiment Videos

  • Employing a single illumination angle, suitable for 2D imaging, unlike conventional angular SPR systems.
  • Incorporating phase-stepping via a moving mirror for accurate phase detection.

    • Main Results:

    • The differential phase measurement significantly enhances detection resolution by eliminating common-mode noise.
    • The 2D SPR phase imaging allows for parallel detection of multiple analytes.
    • The system is compatible with existing microarray chip platforms.

    Conclusions:

    • The developed 2D SPR phase imaging biosensor offers a promising solution for rapid, real-time, and multiplexed analyte detection.
    • This technology has significant potential for the medical device market, particularly in protein quantification and identification.
    • The technique overcomes limitations of conventional SPR by enabling efficient 2D measurements with improved resolution.