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Association between Dental Anomalies and Orofacial Clefts: A Meta-analysis
T Marzouk1,2, I L Alves3, C L Wong2
1Department of Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
JDR Clinical and Translational Research
|October 8, 2020
Summary
Individuals with orofacial clefts (OCs) have a significantly higher frequency of dental anomalies (DAs) compared to those without OCs. This systematic review highlights the strong association between OCs and various DAs, impacting treatment planning.
Area of Science:
- Oral and Maxillofacial Surgery
- Pediatric Dentistry
- Genetics
Background:
- Orofacial clefts (OCs) are common congenital conditions.
- Dental anomalies (DAs) are frequently observed in the general population.
- The association between OCs and DAs requires comprehensive evaluation.
Purpose of the Study:
- To systematically review and meta-analyze the frequency of DAs in individuals with nonsyndromic OCs.
- To compare the prevalence of DAs in individuals with OCs versus those without OCs.
Main Methods:
- Systematic literature search of multiple databases up to February 2020.
- Inclusion of observational studies with original data comparing OC and non-OC groups.
- Random effects meta-analysis using Mantel-Haenszel estimator to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
Main Results:
- Twenty-six studies with 15,213 participants were included.
- Statistically significant associations found between OCs and agenesis (OR 14.2), supernumerary teeth (OR 5.7), enamel defects (OR 5.6), microdontia (OR 14.8), peg-shaped teeth (OR 12.2), taurodontism (OR 1.7), malposition/transposition (OR 5.6), rotation (OR 3.2), and impaction (OR 3.6).
- No significant association was observed for fusion and/or gemination.
Conclusions:
- Individuals with OCs exhibit a significantly higher likelihood of presenting with various DAs.
- Findings underscore the importance of recognizing the link between OCs and DAs for clinical management.
- Awareness of these associations aids in proactive dental treatment planning for patients with OCs.
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