Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Embolism III: Nursing Management01:27

Pulmonary Embolism III: Nursing Management

320
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
320
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

277
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
277
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

464
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
464
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

262
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
262
Pneumothorax-II01:27

Pneumothorax-II

852
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
852
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

3.1K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A UCP1-IRES-Cre Knock-In Mouse Enables Specific Brown Adipocyte Targeting Without CNS Off-Target Expression.

Research square·2026
Same author

Vagal sensory neurons profusely innervate the mouse gall bladder.

Autonomic neuroscience : basic & clinical·2026
Same author

Brunner's Glands in the Duodenal Bulb Are Indirectly Innervated by Vagal Preganglionics That Connect With Cholinergic Enteric Neurons in the Myenteric Plexus.

The Journal of comparative neurology·2026
Same author

FGF21 signals through hindbrain neurons to alter food intake and energy expenditure during dietary protein restriction.

Cell reports·2026
Same author

Obesogenic effects of warm temperature involve feeding adaptation by preoptic area leptin receptor neurons.

Communications biology·2026
Same author

Thromboxane signalling links immune activation to enhanced glucose uptake in skeletal muscle.

Diabetologia·2026

Related Experiment Video

Updated: Jan 8, 2026

Pulmonary Embolism III: Nursing Management
01:27

Pulmonary Embolism III: Nursing Management

Published on: June 19, 2025

320

Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function.

Marie Björnholm1, Heike Münzberg, Rebecca L Leshan

  • 1Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan Medical School, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.

The Journal of Clinical Investigation
|April 7, 2007
PubMed
Summary

Leptin resistance in obesity may stem from a receptor site (Tyr985) that dampens leptin

More Related Videos

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Published on: June 19, 2025

277
Pulmonary Embolism I: Introduction
01:29

Pulmonary Embolism I: Introduction

Published on: June 19, 2025

464

Related Experiment Videos

Last Updated: Jan 8, 2026

Pulmonary Embolism III: Nursing Management
01:27

Pulmonary Embolism III: Nursing Management

Published on: June 19, 2025

320
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Published on: June 19, 2025

277
Pulmonary Embolism I: Introduction
01:29

Pulmonary Embolism I: Introduction

Published on: June 19, 2025

464

Area of Science:

  • Endocrinology
  • Neuroscience
  • Obesity Research

Background:

  • Leptin, an adipose hormone, regulates energy balance by signaling satiety and energy expenditure.
  • Leptin resistance, characterized by high leptin levels and obesity, impairs its weight-loss effects.
  • Leptin receptor (LRb) phosphorylation mediates leptin action, with specific tyrosine residues playing key roles.

Purpose of the Study:

  • To investigate the role of a specific leptin receptor tyrosine residue (Tyr985) in leptin signaling and signal attenuation in vivo.
  • To determine the in vivo function of LRb Tyr985 in mediating leptin's effects on feeding, energy expenditure, and obesity.

Main Methods:

  • Homologous replacement of the wild-type mouse LRb with a mutated version lacking Tyr985.
  • Assessment of neuroendocrine function, feeding behavior, neuropeptide expression, and response to high-fat diet in mutant mice.
  • Evaluation of leptin sensitivity in relation to the Tyr985 mutation.

Main Results:

  • Mice with the LRb Tyr985 mutation were neuroendocrinologically normal.
  • Females with the mutation exhibited reduced feeding, decreased orexigenic neuropeptides, protection from diet-induced obesity, and enhanced leptin sensitivity.
  • These effects were observed in a sex-biased manner, suggesting Tyr985's role in leptin insensitivity.

Conclusions:

  • Leptin receptor Tyr985 mediates autoinhibitory signals that attenuate leptin's anti-obesity effects, particularly in females.
  • This mechanism may contribute to the development of leptin resistance observed in obesity.
  • Targeting LRb Tyr985 signaling could offer novel therapeutic strategies for obesity and metabolic disorders.