Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mapping and ablation: a worldwide perspective.

Carlo Pappone1, Vincenzo Santinelli

  • 1Department of Cardiology, Electrophysiology and Cardiac Pacing Unit, San Raffaele Scientific Institute, Milan, Italy. carlo.pappone@hsr.it

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
|April 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulsed Field Ablation With a Variable Loop Circular Catheter in Atrial Fibrillation: Acute Outcomes From the VARIPURE Multicenter Study.

Heart rhythm·2026
Same author

Tailoring Antiplatelet Therapy Duration After PFO Closure: Insights From the PROLONG Registry.

JACC. Advances·2026
Same author

Catheter ablation of atrial fibrillation in transthyretin and light-chain cardiac amyloidosis: results from the multicentre AMYL-AF study.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same author

Exploring light chain cardiotoxicity in AL amyloidosis: impact on hiPSC-derived cardiomyocyte activity.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis·2026
Same author

Integrated electrophysiological, cellular, and pharmacological profiling reveals variant-specific mechanisms in SCN4A-related myotonia.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Interferometric scattering microscopy supports real-time mass-resolved label-free single-molecule immunoassay.

Scientific reports·2026

Catheter ablation effectively restores sinus rhythm in AF patients, but timely intervention is crucial before AF progresses. Further research is needed to confirm ablation

Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • Atrial fibrillation (AF) management often involves ablative techniques to restore sinus rhythm.
  • Early catheter ablation is recommended for paroxysmal AF to prevent progression to persistent or permanent forms.
  • Current strategies for permanent AF require extensive lesions, mirroring earlier techniques.

Purpose of the Study:

  • To evaluate the long-term efficacy of catheter ablation for AF.
  • To determine optimal timing for AF ablation to prevent disease progression.
  • To compare catheter ablation with medical therapy regarding hard clinical outcomes.

Main Methods:

  • Review of current ablative techniques for AF.
  • Analysis of disease progression from paroxysmal to permanent AF.
  • Discussion of lesion extent required for permanent AF ablation.

Related Experiment Videos

Main Results:

  • Ablative techniques show excellent long-term success in restoring sinus rhythm for paroxysmal and persistent AF.
  • Delayed ablation in progressing AF may necessitate more extensive procedures.
  • Data on hard outcomes (morbidity, mortality) comparing ablation and medical therapy are limited.

Conclusions:

  • Timely catheter ablation is key for managing AF and preventing progression.
  • Extensive atrial lesions may be needed for successful ablation in permanent AF.
  • Long-term randomized trials are essential to define optimal patient selection, risk-benefit, and cost-effectiveness of AF ablation versus medical therapy.