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Updated: Jul 15, 2026
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
Philadelphia variant, t(5;9;22)(q13;q34;q11), in a case with chronic myeloid leukemia
G Balatzenko1, J Grudeva-Popova, T Krustev
1National Centre of Haematology and Transfusiology, Sofia, Bulgaria.
Abstract:
In this paper we report on a case of chronic myeloid leukemia (CML) with a Philadelphia variant involving chromosome 5 as a second change of the standard Philadelphia chromosome (Ph). Molecular analysis found a fusion gene BCR-ABL with participation of exons b3 and a2, respectively (b3a2). The molecular variant of the fusion gene BCR/ ABL or the rare involvement of chromosome 5 could possibly explain the mild course of the disease.
