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Metabolism of parthenin by Beauveria bassiana ATCC 7159
O B Abdel Halim1, G T Maatooq, A M Marzouk
1Department of Pharmacognosy, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt.
Abstract:
Two new metabolites were isolated from the biotransformation reaction of parthenin by Beauveria bassiana ATCC 7159 along with the known naturally occurring sesquiterpene lactones hymenolin and dihydrocoronopilin. The new metabolites: are 3beta,4beta,6beta-trihydroxy-10alphaH,11alpha-methyl-ambrosa-1 -en-12-oic acid-gamma-lactone and 3alpha,6beta-dihydroxy-4beta-hydroperoxy-10alphaH, 11alpha-methyl-ambrosa-1-en-12-oic acid-gamma-lactone. The structure elucidation of these compounds was achieved by different spectroscopic methods.
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