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Changes in cutaneous microcirculation, hemorrheology and platelet aggregation function in dermatomyositis.

C H Liu1, W Su, Y Luo

  • 1Institute of Dermatology, Shanghai Medical University, China.

Journal of Dermatological Science
|September 1, 1991
PubMed
Summary

Dermatomyositis significantly disrupts microcirculation, affecting capillaries and blood flow. Addressing these vascular changes is crucial for effective treatment of this inflammatory disease.

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Area of Science:

  • Rheumatology
  • Vascular Biology
  • Dermatology

Background:

  • Dermatomyositis is an idiopathic inflammatory myopathy.
  • Microcirculatory disturbances are increasingly recognized in autoimmune diseases.

Purpose of the Study:

  • To investigate microcirculatory alterations in dermatomyositis patients.
  • To explore the relationship between microcirculatory changes and disease activity.
  • To identify hemorrheological factors contributing to these alterations.

Main Methods:

  • Observational study of 85 dermatomyositis cases.
  • Capillary microscopy to assess microcirculation.
  • Hemorrheological analysis including plasma viscosity, fibrinogen, erythrocyte, and platelet aggregation.

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Main Results:

  • Observed decreased capillary number, irregular patterns, tortuosity, dilation, slow blood flow, and increased vascular permeability.
  • Microcirculatory changes were more pronounced in patients with visceral involvement and active disease.
  • Blood hyperviscosity was linked to high plasma viscosity, elevated fibrinogen, and increased erythrocyte and platelet aggregation.
  • No correlation found between microcirculatory changes and disease duration.

Conclusions:

  • Microcirculatory dysfunction is a significant feature of dermatomyositis.
  • Hemorrheological abnormalities contribute to impaired blood flow.
  • Modulation of microcirculation should be considered in therapeutic strategies for dermatomyositis.