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Updated: Jul 15, 2026

Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology
Published on: August 18, 2023
Rabies in Western Canada 1978-1984
Rabies diagnosis in Western Canada revealed skunks, bats, and foxes as primary reservoirs. Over 22,500 specimens were tested, with 10.5% of positive cases involving human contact, highlighting public health risks.
Area of Science:
- Veterinary Medicine
- Public Health
- Infectious Diseases
Background:
- Rabies poses a significant zoonotic threat, necessitating accurate diagnostic methods.
- Surveillance of rabies in wildlife is crucial for understanding transmission dynamics and preventing human exposure.
Purpose of the Study:
- To present laboratory diagnostic results for rabies over a seven-year period in Western Canada.
- To identify the primary wildlife reservoirs of rabies in the studied regions.
- To assess the proportion of rabies cases involving human contact.
Main Methods:
- Laboratory examination of 22,503 biological specimens using standard fluorescent antibody (FA) and mouse inoculation tests.
- Geographical data collection from British Columbia, Alberta, Saskatchewan, Yukon, and Northwest Territories.
- Analysis of positive rabies cases to determine animal reservoirs and human contact incidence.
Main Results:
- A total of 1,445 positive rabies cases were identified from 22,503 specimens.
- Skunks, bats, and foxes were identified as the main reservoirs of rabies.
- 10.50% of positive rabies cases involved direct or indirect human contact.
- The fluorescent antibody test demonstrated over 99% agreement with the mouse inoculation test, confirming its reliability.
Conclusions:
- The study reaffirms the efficacy of the fluorescent antibody test for rabies diagnosis.
- Wildlife, particularly skunks, bats, and foxes, are significant reservoirs for rabies in Western Canada.
- A notable percentage of rabies cases involved human contact, underscoring the importance of public health awareness and preventative measures.
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