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Published on: December 18, 2016
Kimura disease
Mohammad Abuel-Haija1, Matthew T Hurford
1Department of Pathology and Laboratory Medicine, Temple University Hospital, 3401 N Broad St, Philadelphia, PA 19140, USA. abuelhaija_m@yahoo.com
Archives of Pathology & Laboratory Medicine
|April 12, 2007
Summary
Kimura disease is a rare chronic inflammatory condition affecting the head and neck. While its cause is unknown, treatments like surgery and steroids offer an excellent prognosis despite potential local recurrence.
Area of Science:
- Immunology
- Dermatology
- Pathology
Background:
- Kimura disease is a rare, benign chronic inflammatory disorder.
- It commonly affects lymph nodes and subcutaneous tissues in the head and neck.
- Characterized by elevated immunoglobulin E and eosinophilia, it predominantly impacts middle-aged Asian men.
Purpose of the Study:
- To summarize the key features, etiology, and management of Kimura disease.
- To highlight the diagnostic markers and treatment options.
- To discuss the prognosis and potential for recurrence.
Main Methods:
- Literature review of Kimura disease cases and studies.
- Analysis of clinical presentation, laboratory findings, and histopathology.
- Evaluation of treatment outcomes and recurrence rates.
Main Results:
- Kimura disease is linked to aberrant chronic immune responses.
- Surgical resection, steroid therapy, and other modalities are used for treatment.
- The disease generally has an excellent prognosis but can recur locally.
Conclusions:
- Kimura disease is a distinct inflammatory entity with specific clinical and laboratory findings.
- Multimodal treatment approaches are effective in managing the condition.
- Long-term monitoring is advisable due to the possibility of local recurrence.
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