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Updated: Jul 15, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
[Depression and the complete state model of health]
Darío Díaz1, Amalio Blanco, Javier Horcajo
1Universidad Autónoma de Madrid. dario.diaz@uam.es
Abstract:
Health is a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity. In order to specify the contents of this positive state, the Complete State Model of Health (CSMH) considers mental health as a series of symptoms of hedonia and positive functioning, operationalized by measures of subjective, psychological, and social well-being. This model has empirically confirmed two new axioms: (a) rather than forming a single bipolar dimension, health and illness are correlated unipolar dimensions, and (b) the presence of mental health implies positive personal and social functioning. In the present article, we have taken the CSMH as the theoretical framework for the study of depression. Confirmatory factor analyses did not support the first axiom. In fact, the model that posits that measures of mental illness and health form a single bipolar dimension provided the best fit to the data.
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