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Circulating endothelial cells in preeclampsia.

B Canbakan¹, K Keven, H Tutkak

¹Department of Nephrology, Ankara University School of Medicine, Ibni Sina Hospital, Ankara 06100, Turkey. bcanbakan61@yahoo.com

Journal of Human Hypertension

|April 13, 2007

Summary

Circulating endothelial cells (CECs) are significantly elevated in preeclampsia, indicating endothelial injury. Higher CECs correlate with increased blood pressure and homocysteine levels in preeclamptic patients.

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Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

Area of Science:

Obstetrics and Gynecology
Cardiovascular Research
Vascular Biology

Background:

Endothelial dysfunction is a key factor in preeclampsia development.
Elevated circulating endothelial cells (CECs) are associated with various endothelial injury conditions.
Homocysteine is recognized as a marker of vascular injury.

Purpose of the Study:

To quantify CECs in preeclamptic patients.
To investigate the association between CECs and homocysteine levels in preeclampsia.
To compare CEC levels with other hypertensive and healthy pregnant/non-pregnant groups.

Main Methods:

Peripheral blood samples were collected from preeclamptic, hypertensive, healthy pregnant, and non-pregnant women.
Circulating endothelial cells (CECs) were isolated using anti-CD-146 antibody and immunomagnetic beads.
Serum homocysteine levels, systolic and diastolic blood pressures were measured.

Main Results:

Preeclamptic patients exhibited significantly higher CEC counts compared to all other groups (P<0.0001).
Serum homocysteine levels were elevated in preeclamptic patients compared to healthy pregnant women (P<0.0001).
Significant positive correlations were observed between CECs and systolic blood pressure (r=0.63), diastolic blood pressure (r=0.64), and serum homocysteine (r=0.55) in preeclamptic patients.

Conclusions:

CECs are a significant marker of endothelial injury in preeclampsia.
Elevated CECs in preeclampsia suggest substantial endothelial damage.
Further research is warranted to explore the prognostic value of CECs in preeclampsia.