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ProCMD: a database and 3D web resource for protein C mutants.

Pasqualina D'Ursi1, Francesca Marino, Andrea Caprera

  • 1Department of Science and Biomedical Technologies, University of Milano, Italy. pasqualina.dursi@itb.cnr.it

BMC Bioinformatics
|April 14, 2007
PubMed
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A new database, ProCMD, provides integrated functional and structural data for protein C mutants. This resource aids research into how molecular defects in protein C lead to thrombosis and other diseases.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Computational Biology

Background:

  • Activated Protein C (ProC) is a serine protease regulating anticoagulation, inflammation, and cell proliferation.
  • Mutations in the protein C gene are linked to functional deficiency and venous thrombosis risk.
  • Computational analysis aids understanding of molecular mechanisms in thrombophilia.

Purpose of the Study:

  • To develop a specialized database and search tool for natural protein C mutants.
  • To integrate genetic, functional, and structural data for protein C variants.
  • To provide tools for visualizing and analyzing mutant protein C structures.

Main Methods:

  • Creation of a relational database containing 195 protein C mutations (182 missense, 13 stop).

Related Experiment Videos

  • Development of a menu-driven search engine for retrieving variant information.
  • Implementation of interactive tools for visualizing 3D molecular models and generating alignments.

    • Main Results:

    • The database includes 195 entries with detailed genetic and structural data for protein C mutants.
    • Users can retrieve information, visualize molecular models, and access PDB coordinates.
    • An interface allows for the generation of multiple alignments and 3D models for new variants.

    Conclusions:

    • ProCMD is an interactive database integrating phenotypical, functional, and structural data for protein C mutants.
    • The database facilitates research and clinical understanding of molecular defects leading to disease.
    • ProCMD is accessible to academics at http://www.itb.cnr.it/procmd/.