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Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Gastrointestinal manifestations in patients with common variable immunodeficiency
Ahmad Khodadad1, Asghar Aghamohammadi, Nima Parvaneh
1Department of Pediatrics, Division of Gastroenterology, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Gastrointestinal issues are common in common variable immunodeficiency (CVID) patients, with chronic diarrhea being the most frequent symptom. Early diagnosis of these GI complications is crucial for improving patient well-being.
Area of Science:
- Gastroenterology
- Immunology
- Pathology
Background:
- Common variable immunodeficiency (CVID) is associated with an increased risk of gastrointestinal (GI) infections and inflammatory conditions.
- GI problems contribute significantly to morbidity in CVID patients, second only to respiratory complications.
Purpose of the Study:
- To investigate the endoscopic and pathologic findings of GI disorders in Iranian patients with CVID.
- To identify the prevalence and characteristics of GI complaints in this patient cohort.
Main Methods:
- Retrospective analysis of endoscopic and biopsy data from 39 CVID patients.
- Correlation of GI findings with clinical symptoms such as chronic diarrhea, anemia, and CD4+ T cell counts.
Main Results:
- 48% of CVID patients reported GI complaints, with chronic diarrhea being the most common (28%).
- Duodenal biopsies showed villous atrophy in 8 patients and nodular lymphoid hyperplasia in 3.
- Colon biopsies revealed chronic noncrypt-destructive colitis in 3 patients. No significant association was found between duodenal villous atrophy and chronic diarrhea, anemia, or CD4+ T cell counts.
Conclusions:
- Gastrointestinal complications are a significant health concern for CVID patients.
- Endoscopic and pathologic evaluations are essential for diagnosing GI issues in CVID.
- Timely diagnosis and management of GI problems can enhance the quality of life for CVID patients.
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