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Published on: October 11, 2024
Fibrin glue enhances early hearing recovery in tympanoplasty: A randomised controlled trial
Benyamin Rahmaty1, Sanam Asgari2, Mohammad Sayyadi3
1Department of Otorhinolaryngology-Head and Neck Surgery, Arak University of Medical Sciences, Arak, Iran; Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Objective:
To compare the efficacy of fibrin glue versus Gelfoam in cartilage tympanoplasty, focusing on graft uptake rates and short-term hearing outcomes.
Methods:
In this double-blind, randomised clinical trial, forty-six patients with dry tympanic membrane perforations were randomly allocated to two groups: fibrin glue with cartilage graft (Group A) and Gelfoam with cartilage graft (Group B). A single surgeon carried out all surgeries. Graft integrity and air-bone gap (ABG) closure (≤15 dB) were evaluated three months post-surgery.
Results:
Graft uptake rates were 91.3% in the fibrin group and 82.6% in the Gelfoam group (p > 0.05). However, ABG closure ≤15 dB was achieved in 87% of the fibrin group compared to 60.9% of the Gelfoam group (p = 0.044), indicating a significant improvement in early hearing outcomes.
Conclusion:
Fibrin glue tympanoplasty achieved comparable graft uptake rates to conventional Gelfoam tympanoplasty, while providing superior short-term hearing improvement. Both techniques demonstrated comparable graft integration, while fibrin glue was associated with superior early hearing recovery.
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