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Functional Surface-immobilization of Genes Using Multistep Strand Displacement Lithography
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A versatile method for direct and covalent immobilization of DNA and proteins on biochips

Benjamin P Corgier1, Alain Laurent, Pascal Perriat

  • 1Laboratoire de Génie Enzymatique et Biomoléculaire, UMR 5246, Institut de Chimie et Biochimie Moléculaire et Supramoléculaire, CNRS-Université Lyon 1, Villeurbanne, France.

Angewandte Chemie (International Ed. in English)
|April 14, 2007
PubMed
Abstract

No abstract available in PubMed .

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DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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