Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal changes in DTI-ALPS and choroid plexus volume relative to CSF biomarkers during lecanemab treatment in mild cognitive impairment: A pilot study.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes.

Frontiers in aging neuroscience·2025
Same author

Cerebral Small Vessel Disease and Alzheimer Disease: The Vascular Link Through MRI Diffusion.

Neurology·2025
Same author

CSEPC: a deep learning framework for classifying small-sample multimodal medical image data in Alzheimer's disease.

BMC geriatrics·2025
Same author

Changes in Distributed Motor Network Connectivity Correlates With Functional Outcome After Surgical Resection of Brain Tumors.

Neurosurgery practice·2025
Same author

Cortical involvement of lateral trunk flexion and verticality misperception in Parkinson's disease.

Brain communications·2025

Related Experiment Video

Updated: Jul 15, 2026

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

[Neuroimaging in mild cognitive impairment].

Hidenao Fukuyama1

  • 1Human Brain Research Center, Kyoto University Graduate School of Medicine.

Rinsho Shinkeigaku = Clinical Neurology
|April 17, 2007
PubMed
Summary

Neuroimaging studies, including SPECT and PET scans, track mild cognitive impairment (MCI) progression to Alzheimer's disease. Research highlights parietal and frontal hypoperfusion in MCI converters, with ongoing investigations into posterior cingulate gyrus connectivity.

Area of Science:

  • Neuroimaging
  • Cognitive Neurology
  • Neurodegeneration

Context:

  • Mild cognitive impairment (MCI) is a transitional stage between normal aging and Alzheimer's disease (AD).
  • Neuroimaging plays a crucial role in understanding the pathophysiology of MCI and predicting conversion to AD.
  • Large-scale, multi-center studies like J-COSMIC and ADNI are advancing the field.

Purpose:

  • To summarize the current status of neuroimaging studies in mild cognitive impairment (MCI).
  • To compare the efficacy of cognitive evaluation methods.
  • To investigate the neural underpinnings of MCI progression using advanced imaging techniques.

Summary:

  • The J-COSMIC study (Japan Cooperative SPECT Study on Assessment of Mild Impairment of Cognitive Function) tracks MCI patients using SPECT, with a subset converting to AD.

More Related Videos

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

Related Experiment Videos

Last Updated: Jul 15, 2026

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

  • MCI patients who convert to Alzheimer's disease exhibit hypoperfusion in parietal and frontal regions, consistent with prior research.
  • Advanced techniques like molecular imaging for amyloid deposition and diffusion-weighted imaging for fiber tract analysis are being explored to understand early AD/MCI changes.

    • Impact:

    • Findings suggest general cognitive evaluations like MMSE may be more reliable than memory-specific tests (WMS-R) for tracking MCI.
    • Identifying specific neuroimaging biomarkers could aid in the early diagnosis and prediction of MCI conversion to AD.
    • Investigating the functional connectivity of brain regions like the posterior cingulate gyrus may elucidate pathophysiological mechanisms in MCI and AD.