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Changes in Distributed Motor Network Connectivity Correlates With Functional Outcome After Surgical Resection of
Yukihiro Yamao1, Nobukatsu Sawamoto2,3, Takeharu Kunieda1,4
1Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Neurosurgery Practice
|February 17, 2025
Summary
Supplementary motor area syndrome after brain tumor surgery is linked to disrupted functional connectivity in motor networks, not damaged anatomical pathways. This impacts motor performance following brain tumor resection.
Area of Science:
- Neuroscience
- Neurosurgery
- Functional Neuroimaging
Background:
- Brain tumors near motor cortices can impair motor function.
- Resection of the medial premotor area (PM) may lead to supplementary motor area syndrome.
Purpose of the Study:
- To investigate the neural mechanisms behind postsurgical motor deficits.
- To differentiate between functional and anatomical connectivity changes.
Main Methods:
- Case-control study of 12 brain tumor patients with pre- and post-operative assessments.
- Used resting-state and task-based fMRI to evaluate functional connectivity.
- Probabilistic tractography assessed anatomical connectivity of motor networks.
Main Results:
- Reduced functional connectivity in motor areas (M1, PMs) post-surgery in patients with deficits.
- Anatomical connectivity of the corticofugal pathway remained largely intact.
- Motor-evoked potentials were preserved, supporting intact corticofugal pathways.
Conclusions:
- Supplementary motor area syndrome results from disorganized functional connectivity within cortical motor networks.
- Disruption of anatomical pathways is less likely the cause of this syndrome.
Keywords:
Large scale networkPremotor areaPrimary motor areaResting-state functional MRISMA syndromeTractography
