Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Stem cell based cell therapy for muscular dystrophy].

Shin'ichi Takeda1

  • 1Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry.

Rinsho Shinkeigaku = Clinical Neurology
|April 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prostaglandin E2 receptor EP2 is indispensable for maintenance of skeletal muscle stem cells.

Stem cells (Dayton, Ohio)·2026
Same author

RNA therapies are delivering as therapies for neuromuscular dystrophy patients: Editorial for the special issue on RNA therapies in Journal of Neuromuscular Diseases.

Journal of neuromuscular diseases·2025
Same author

Digital Outcome Measures for Gait and Spontaneous Locomotor Activity in Dystrophic Dogs.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Direct Reprogramming of Human DMD Fibroblasts into Myotubes for In Vitro Evaluation of Antisense-Mediated Exon Skipping and Exons 45-55 Skipping Accompanied by Rescue of Dystrophin Expression.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

In Vitro Multiexon Skipping by Antisense PMOs in Dystrophic Dog and Exon 7-Deleted DMD Patient.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

In Vivo Evaluation of Multiple Exon Skipping with Peptide-PMOs in Cardiac and Skeletal Muscles in Dystrophic Dogs.

Methods in molecular biology (Clifton, N.J.)·2025
Same journal

[Utility of acute-phase cerebral blood flow single photon emission computed tomography (SPECT) for evaluating the pathophysiology of Bickerstaff brainstem encephalitis with decorticate posturing].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Successful treatment with rituximab in unilateral relapsing primary CNS vasculitis: a ‍case report].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Clinical management of headache comorbid with functional neurological disorder].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Transient myoclonic state with asterixis related to COVID-19].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Let's present at a regional meeting].

Rinsho shinkeigaku = Clinical neurology·2026
Same journal

[Editor's Note].

Rinsho shinkeigaku = Clinical neurology·2026
See all related articles

Researchers identified novel genes in quiescent satellite cells and found that side population (SP) cells synergistically promote muscle regeneration, advancing stem cell therapy for muscular dystrophy.

Area of Science:

  • Muscle stem cell biology
  • Regenerative medicine
  • Genetic engineering

Context:

  • Muscular dystrophy presents a significant challenge for cell therapy.
  • Muscle satellite cells and side population (SP) cells are promising stem cell sources.
  • Understanding quiescent satellite cell regulation is crucial.

Purpose:

  • To identify novel genes specific to quiescent satellite cells.
  • To evaluate the therapeutic potential of purified satellite cells and SP cells in muscular dystrophy models.
  • To investigate the role of SP cells in muscle regeneration.

Summary:

  • Novel quiescent satellite cell-specific genes were identified using DNA microarray analysis.
  • Purified satellite cells transduced with lentivirus effectively integrated into dystrophin-deficient muscle and expressed dystrophin.

Related Experiment Videos

  • A novel population of muscle side population (SP) cells was identified, with CD31-/CD45- SP cells proliferating during regeneration and synergistically promoting it with satellite cells.

    • Impact:

    • This study provides insights into the molecular mechanisms governing muscle stem cell dormancy and activation.
    • The findings support the potential of combined satellite cell and SP cell transplantation for enhanced muscular dystrophy therapy.
    • Further research into the molecular basis of muscle stem cells and regeneration is essential for effective cell-based treatments.