Related Experiment Video

Updated: Jul 7, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

[Clinical management of headache comorbid with functional neurological disorder]

Takayoshi Shimohata1

  • 1Department of Neurology, Gifu University Graduate School of Medicine.

Rinsho Shinkeigaku = Clinical Neurology
|July 5, 2026
PubMed

Insights

Headache and migraine are common in functional neurological disorder (FND) but often missed. Comorbid migraine worsens FND, suggesting shared mechanisms and the need for integrated treatment.

Area of Science:

  • Neurology
  • Neuroscience
  • Psychiatry

Background:

  • Headache, especially migraine, is highly prevalent in patients with functional neurological disorder (FND).
  • This comorbidity is frequently underrecognized in clinical practice.
  • Migraine significantly increases disease severity and clinical complexity in FND patients.

Purpose of the Study:

  • To review the existing literature on the association between FND and headache.
  • To highlight the impact of comorbid migraine on FND.
  • To discuss potential shared pathophysiological mechanisms and clinical implications.

Main Methods:

  • Literature review of studies examining the relationship between FND and headache/migraine.
  • Analysis of clinical data regarding disease severity and complexity in comorbid cases.
  • Exploration of potential overlapping biological pathways.

Main Results:

  • A high prevalence of headache and migraine in FND patients was confirmed.
  • Comorbid migraine is linked to worse FND outcomes and greater complexity.
  • Evidence suggests potential shared pathophysiological mechanisms between FND and migraine.

Conclusions:

  • Migraine is a significant comorbidity in FND, impacting disease severity.
  • Clinicians must be vigilant to avoid underdiagnosis and overdiagnosis of both conditions.
  • An integrated therapeutic approach is essential for managing comorbid FND and migraine.
Keywords:
functional neurological disordermigrainepositive signspredictive codingtreatment

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