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[Herpes simplex encephalitis in childhood].

Hiroshi Kimura¹

¹Department of Virology, Nagoya University Graduate School of Medicine.

Rinsho Shinkeigaku = Clinical Neurology

|April 17, 2007

Summary

This summary is machine-generated.

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Central nervous system (CNS) infections in children, including herpes simplex encephalitis, have improved survival rates due to early diagnosis and antiviral treatments. However, neurological complications persist, prompting recommendations for longer, higher-dose acyclovir therapies.

Area of Science:

Neurology
Virology
Pediatrics

Context:

Central nervous system (CNS) infections by herpes simplex virus (HSV) in childhood encompass herpes simplex encephalitis and neonatal CNS infections.
Neonatal CNS infections differ pathogenetically and clinically from adult herpes simplex encephalitis.
Herpes simplex encephalitis in children shares similarities with adult cases.

Purpose:

To differentiate the pathogenesis and clinical features of CNS infections in neonates versus children and adults.
To highlight advancements in diagnosing and treating childhood CNS HSV infections.
To address the persistent issue of neurological morbidity and relapses despite current therapies.

Summary:

Herpes simplex virus type 1 (HSV-1) causes herpes simplex encephalitis via trans-neuronal transmission in children and adults.

Related Experiment Videos

Hematogenous spread of HSV-1 or HSV-2 causes CNS infections in neonates.

Early diagnosis via PCR and antiviral therapies have improved mortality for childhood CNS HSV infections.

Neurological morbidity remains a challenge, with some HSV infections relapsing post-acyclovir therapy.

Impact:

Improved survival rates for CNS infections by herpes simplex virus in childhood.
Persistent neurological morbidity and potential for relapse necessitate revised treatment strategies.
Recent recommendations advocate for extended acyclovir therapy with increased dosages for childhood CNS infections.