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Related Experiment Video

Updated: Jul 15, 2026

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

Prostate cancer screening.

P Tenke¹, J Horti, P Balint

¹Department of Urology, Jahn Ferenc South-Pest Hospital, Budapest, Hungary.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer

|April 17, 2007

Summary

Prostate cancer screening using PSA tests can detect slow-growing cancers, but may lead to unnecessary biopsies. Informed patient-physician discussions are crucial for personalized prostate cancer screening decisions.

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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

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Published on: November 7, 2025

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Last Updated: Jul 15, 2026

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Area of Science:

Oncology
Urology
Public Health

Background:

Prostate cancer is a significant cause of cancer incidence and mortality in the US.
Early detection of prostate cancer through PSA screening and DRE has led to stage migration and decreased metastatic disease.
The natural history of prostate cancer is complex, with slow-growing forms having a relatively good prognosis.

Purpose of the Study:

To evaluate the benefits and drawbacks of prostate cancer screening programs.
To discuss the implications of early detection on identifying both aggressive and non-aggressive prostate cancers.
To advocate for an evidence-based approach to prostate cancer screening that prioritizes patient outcomes.

Main Methods:

Review of evidence supporting PSA screening in conjunction with DRE for early prostate cancer detection.
Analysis of the impact of widespread screening on disease staging and mortality rates.
Discussion of the limitations of PSA testing, including poor specificity in men with benign prostatic hyperplasia (BPH).

Main Results:

Widespread prostate cancer screening has resulted in earlier detection and a decrease in metastatic disease at diagnosis.
PSA screening has a poor specificity in men with BPH, leading to increased biopsies and associated costs/morbidity.
Early detection is more likely to identify slow-growing prostate cancers, while aggressive cancers may progress rapidly.

Conclusions:

Mass prostate cancer screening programs may be premature due to the detection of indolent cancers and the limitations of PSA testing.
Individualized screening decisions, involving informed patient-physician discussions about risks and benefits, are recommended over mass screening.
Future research should focus on evidence-based strategies to improve patient outcomes and quality of life for those at risk of or diagnosed with prostate cancer.