Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thalidomide and its dermatologic uses.

Kapila V Paghdal1, Robert Schwartz

  • 1Department of Dermatology, New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, USA. roschwar@cal.berkeley.edu

Acta Dermatovenerologica Croatica : ADC
|April 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Policy pathways and historical insights: Canada's evolving approach to psychedelic access for end-of-life distress.

The International journal on drug policy·2026
Same author

Drug Use, Treatment, and Hopes for the Future: A Qualitative Study of Patients on Methadone Who Use Cocaine in the Age of Fentanyl.

Substance use & addiction journal·2026
Same author

Baseline quitting self-efficacy as a predictor of duration of vaping abstinence in a vaping cessation intervention.

Addictive behaviors·2026
Same author

Silk sericin enhances in vitro wound healing, modulates cytokeratin 16 and 17 expression, and exhibits immunomodulatory effects: an in vitro study for potential biomedical applications.

International journal of biological macromolecules·2026
Same author

Management of Dry Eye Disease Pre- and Post-Cataract Surgery: A Personalized Approach.

Journal of personalized medicine·2026
Same author

Stigma, Scarcity and the Price of Legitimacy: Chronic Pain Advocacy and the Politics of Pharmaceutical Partnerships in Canada.

Sociology of health & illness·2026

Thalidomide effectively treats various skin conditions. Its analogues, lenalidomide and CC-4047, offer enhanced potency and fewer side effects, showing promise in ongoing trials for immunomodulatory and anti-angiogenic therapies.

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Thalidomide is a key treatment for refractory dermatologic disorders like erythema nodosum leprosum and pyoderma gangrenosum.
  • Existing treatments often have limitations, necessitating exploration of alternative therapies.

Purpose of the Study:

  • To review the therapeutic applications of thalidomide in dermatology.
  • To introduce potent thalidomide analogues, lenalidomide and CC-4047, as promising alternatives.

Main Methods:

  • Literature review of thalidomide's efficacy in various dermatologic conditions.
  • Overview of preclinical and clinical data for thalidomide analogues.

Main Results:

  • Thalidomide demonstrates significant benefits in treating conditions such as lupus erythematosus, prurigo nodularis, and aphthous stomatitis.

Related Experiment Videos

  • Lenalidomide and CC-4047 exhibit greater potency and improved safety profiles compared to thalidomide.
  • These analogues possess enhanced immunomodulatory and anti-angiogenic properties.

    • Conclusions:

    • Thalidomide remains a valuable therapeutic option for severe dermatologic diseases.
    • Thalidomide analogues represent a significant advancement, offering improved treatment outcomes with potentially reduced adverse effects.