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Molecular implications of evolutionary differences in CHD double chromodomains.

John F Flanagan1, Bartlomiej J Blus, Daesung Kim

  • 1Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908, USA.

Journal of Molecular Biology
|April 17, 2007
PubMed
Summary

Yeast CHD1 double chromodomains cannot bind histone H3 tails due to structural differences. This study reveals evolutionary specialization in CHD double chromodomains, impacting their targeting capabilities.

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