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Updated: Jul 15, 2026
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
Atherosclerosis: the path from genomics to therapeutics
David T Miller1, Paul M Ridker2, Peter Libby3
1Division of Hematology, Brigham and Women's Hospital, Boston, Massachusetts; Donald W. Reynolds Cardiovascular Clinical Research Center on Atherosclerosis at Brigham and Women's Hospital and the Harvard Medical School, Boston, Massachusetts.
Journal of the American College of Cardiology
|April 17, 2007
Summary
Genomic technologies are revolutionizing cardiovascular medicine by uncovering disease mechanisms and therapeutic targets for conditions like atherosclerosis. Collaborative efforts are crucial for translating these genetic discoveries into clinical practice.
Area of Science:
- Cardiovascular Medicine
- Genomics
- Proteomics
- Metabolomics
Background:
- Rapid advancements in genomic tools and techniques offer transformative potential for cardiovascular medicine.
- Resources like the Human Genome Project and high-throughput technologies enable deeper investigation into cardiovascular diseases.
Purpose of the Study:
- To explore how genomic, proteomic, and metabolomic studies can enhance understanding of complex cardiovascular diseases, particularly atherosclerosis.
- To identify genes and pathways involved in atherosclerosis predisposition and pathophysiology.
- To refine understanding of the atherosclerotic vascular wall and discover therapeutic targets.
Main Methods:
- Utilizing genomic, proteomic, and metabolomic approaches.
- Applying high-throughput genotyping and gene expression profiling.
- Employing advanced statistical analysis methods.
Main Results:
- Genomic studies bridge epidemiology and basic biology for improved cardiovascular disease process understanding.
- Genetic approaches identify key genes and pathways in atherosclerosis.
- Gene expression profiling reveals the dynamic nature of the atherosclerotic vascular wall.
Conclusions:
- Translating genetic and omic information into clinical practice presents unprecedented opportunities.
- Validation in large, independent cohorts through collaborative efforts is essential for clinical translation.
- Continued success hinges on ongoing cooperation within the cardiovascular research community.
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