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Related Concept Videos

Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Sedatives and Hypnotics Drugs: Barbiturates01:20

Sedatives and Hypnotics Drugs: Barbiturates

Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A key...

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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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[Rectal pentobarbital sedation for children undergoing auditory brainstem response testing].

F Baculard1, A Rieutord, A Eslami

  • 1Service d'ORL et de Chirurgie Cervicofaciale Pédiatrique, Hôpital Robert-Debré, APHP, 75019 Paris cedex 19, France. flbaculard@free.fr

Annales D'Oto-Laryngologie Et De Chirurgie Cervico Faciale : Bulletin De La Societe D'Oto-Laryngologie Des Hopitaux De Paris
|April 17, 2007
PubMed
Summary

Rectal pentobarbital sodium is a safe and effective sedation method for pediatric auditory brainstem response (ABR) testing. This approach offers a painless, brief-acting alternative to general anesthesia for young children.

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Published on: September 3, 2020

Area of Science:

  • Pediatric Anesthesiology
  • Neuroscience
  • Pharmacology

Context:

  • Auditory Brainstem Response (ABR) testing is crucial for pediatric hearing assessments.
  • Sedation is often required for young children to ensure accurate ABR results.
  • General anesthesia poses risks and logistical challenges for ABR procedures.

Purpose:

  • To evaluate the safety and efficacy of rectal pentobarbital sodium for sedating children undergoing ABR testing.
  • To compare rectal pentobarbital sodium with other sedation methods, including general anesthesia.

Summary:

  • A prospective study involved 68 children under 8 years old receiving rectal pentobarbital (5 mg/kg) for ABR.
  • Adequate sedation was achieved in 89.7% of cases, with a mean time to sedation of 36.1 minutes.
  • No adverse events were reported in 84.1% of the children, indicating a favorable safety profile.

Impact:

  • Rectal pentobarbital sodium provides a safe, effective, and well-tolerated sedation option for pediatric ABR.
  • This method is easy to administer, painless, and has a short duration of action.
  • It presents a viable alternative to general anesthesia, improving the feasibility of ABR testing in young children.