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High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
Published on: July 17, 2014
Rational approaches to developing an anti-disease vaccine against malaria
1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Australia. schofield@wehi.edu.au
Abstract:
Vaccination against pathogen toxins provides a rational approach to prevent morbidity and mortality, and is widely validated in the context of bacterial infections. A saccharide-conjugate vaccine targeting the malaria glycosylphosphatidylinositol toxin glycan could therefore prevent severe disease. This strategy could also reduce the risk posed by 'rebound' infections or immunopathology associated with other interventions.
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