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Multisystem evaluation in one case of pure autonomic failure
L Santangelo1, G Mandarino, L De Biase
1Institute of Mental and Nervous Diseases, La Sapienza University, Rome, Italy.
Functional Neurology
|July 1, 1991
Summary
Pure autonomic failure (PAF) is a rare autonomic nervous system (ANS) disorder. This study highlights the necessity of comprehensive autonomic function testing for accurate PAF diagnosis in affected individuals.
Area of Science:
- Neurology
- Cardiology
- Urology
Background:
- Pure autonomic failure (PAF) is a rare syndrome involving the autonomic nervous system (ANS).
- Understanding the full spectrum of PAF manifestations is crucial for diagnosis and management.
- Autonomic dysfunction can impact multiple organ systems.
Observation:
- A 53-year-old woman with suspected PAF underwent extensive autonomic function testing.
- Tests included cardiovascular, ocular innervation, and bladder function assessments.
- Cardiovascular tests comprised standing up, controlled ventilation, Valsalva maneuver, handgrip, cold pressor, and mental stress tests, along with plasma catecholamine levels.
Findings:
- The patient exhibited abnormalities across all assessed parameters.
- Cardiovascular system, intrinsic ocular innervation, and bladder function were all affected.
- Results underscore the widespread impact of autonomic failure.
Implications:
- Accurate diagnosis of PAF requires a multidisciplinary approach.
- Comprehensive autonomic evaluation is essential for identifying PAF.
- Early and accurate diagnosis can guide patient management and improve outcomes.