Related Experiment Video
Updated: Jul 15, 2026

Sleeve Gastrectomy in Mice using Surgical Clips
Published on: November 14, 2020
[Can bariatric surgery cure metabolic syndrome?]
Perseu Seixas de Carvalho1, Cora Lavigne de C B Moreira, Melina da Costa Barelli
1Serviço de Endocrinologia, Hospital Universitário Cassiano Antônio Moraes. perseu@npd.ufes.br
Objectives:
To evaluate the impact of bariatric surgery on the metabolic syndrome (MS) and what are the criteria that contribute the most for its exclusion after surgery. The progress of leucometry was also analyzed.
Methods And Procedures:
47 obese women with MS were evaluated. All patients were operated with the Roux-en-Y vertical gastric bypass technique, with the insertion of a contention ring on the gastro-jejune anastomosis (Fobi-Capella). Patients were evaluated before and on the first year post-surgery.
Results:
Fasting glucose presented a relevant decrease at 3 months after surgery. After 12 months, all 20 patients who had DM2 or altered fasting glucose presented normal levels of fasting glucose and glicated hemoglobin, and none of them was using any anti-diabetic drug. Triglycerides levels were reduced by 49.2%, whereas HDL-cholesterol increased by 27.2%. Systolic and diastolic blood pressures were reduced by an average of 28.7 and 20.8 mmHg, respectively. Leucocytes counting fell from 7671/microL to 6156/microL. Fasting glucose, triglycerides, DBP, SBP and HDL-cholesterol were the variables that contributed most for the reduction of MS. At the end of the first year, elimination of MS occurred in 80.9% of the patients.
Discussion:
Bariatric surgery reduces resistance to insulin and consequently the cardiovascular risk factors.
Related Concept Videos
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Obesity
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in the...
Type II Diabetes II: Pathophysiology
Type II Diabetes I: Introduction
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

