Related Experiment Videos
Hodgkin's lymphoma initially presenting with polymyalgic symptoms: a case report
Mehmet Sahin1, Guchan Alanoglu, Oguzhan Aksu
1Division of Rheumatology, Department of Internal Medicine, Suleyman Demirel University School of Medicine, TR-32260 Isparta, Turkey. mehmetsahin66@hotmail.com
Modern Rheumatology
|April 18, 2007
Summary
Polymyalgic symptoms can be a rare sign of Hodgkin
Area of Science:
- Oncology
- Rheumatology
- Internal Medicine
Background:
- The link between polymyalgic symptoms and lymphoma is uncommon, with unclear pathogenesis.
- Polymyalgia rheumatica (PMR) is an inflammatory condition that causes muscle pain and stiffness.
Observation:
- A 75-year-old man presented with polymyalgic symptoms mimicking PMR.
- Initial malignancy investigations were negative; corticosteroid treatment provided temporary relief.
- Symptoms recurred upon tapering corticosteroids, preceding lymph node enlargement.
Findings:
- Lymph node biopsy confirmed Hodgkin's lymphoma.
- Both lymphadenopathy and musculoskeletal symptoms resolved with chemotherapy.
Implications:
- Hodgkin's lymphoma should be considered in the differential diagnosis of PMR.
- Musculoskeletal syndromes may indicate paraneoplastic manifestations of an evolving neoplasm.
- Early detection of malignancy is crucial for effective treatment of associated symptoms.
Related Concept Videos
01:27Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
01:17Poliomyelitis
Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
01:15Myasthenia Gravis: Diagnostic Tests
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
01:22Myasthenia Gravis ll: Pathophysiology
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
01:14Atypical Pneumonia
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...