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Tissue and fluid penetration of garenoxacin in surgical patients

Charles E Edmiston1, Candace J Krepel, Gary R Seabrook

  • 1Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA. edmiston@mcw.edu

Surgical Infections
|April 18, 2007
PubMed
Abstract

Insights

Garenoxacin, a novel antibiotic, showed excellent penetration into various human tissues and fluids after a single oral dose. These concentrations suggest efficacy against common pathogens in sinus, skin, and abdominal infections.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Drug Metabolism and Pharmacokinetics

Background:

  • Garenoxacin is a novel des-F(6)-quinolone with broad-spectrum antimicrobial activity.
  • It is effective against clinically significant aerobic and anaerobic pathogens.

Purpose of the Study:

  • To evaluate the penetration of garenoxacin into various human tissues and fluids.
  • To determine garenoxacin concentrations relative to plasma levels after a single oral dose.

Main Methods:

  • Thirty patients (ages 20-83) undergoing elective surgery received a single 600 mg oral dose of garenoxacin.
  • Blood and tissue specimens were collected 3-5 hours post-dose.
  • Garenoxacin concentrations were measured using validated liquid chromatography/tandem mass spectrometry assays.

Main Results:

  • Mean concentrations (mcg/mL or mcg/g) were: plasma 5.71, bile 7.59, adipose tissue 0.90, subcutaneous tissue 1.19, incisional skin 3.06, striated muscle 3.92, bone 2.82, sinus mucosa 5.26, liver 1.84, gallbladder 11.59, large intestine 12.13, small intestine 15.66, and mesenteric lymph node 3.10.
  • Concentrations varied significantly across different tissues and fluids.

Conclusions:

  • Garenoxacin demonstrates good penetration into selected human tissues and fluids after a single 600 mg oral dose.
  • Achieved concentrations at 3-5 hours post-dose exceeded the minimum inhibitory concentration-90% for many targeted pathogens.
  • These findings suggest garenoxacin's potential efficacy in treating sinus, skin, and intra-abdominal infections.

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