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Updated: Jul 15, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Cyanobacterial clock, a stable phase oscillator with negligible intercellular coupling.

M Amdaoud¹, M Vallade, C Weiss-Schaber

¹Laboratoire de Spectrométrie Physique, Centre National de la Recherche Scientifique/Unité Mixte de Recherche 5588, Université Joseph Fourier-Grenoble I, BP 87, 38402 St. Martin d'Hères Cedex, France.

Proceedings of the National Academy of Sciences of the United States of America

|April 18, 2007

Summary

Cyanobacterial circadian clocks maintain accuracy despite cellular noise. This study demonstrates that clock stability is an intrinsic property, not due to intercellular communication, as coupling effects are negligible.

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Last Updated: Jul 15, 2026

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Published on: September 27, 2012

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Area of Science:

Cellular Biology
Biophysics
Systems Biology

Background:

Cellular functions require accuracy despite molecular noise.
Cyanobacteria possess a resilient circadian oscillator.
Resilience may stem from intercellular communication or intrinsic network properties.

Purpose of the Study:

Investigate the role of intercellular communication in cyanobacterial circadian clock resilience.
Differentiate the effects of intercellular coupling from intrinsic noise resilience.
Quantify the intercellular coupling strength in cyanobacteria.

Main Methods:

Theoretical modeling of interacting noisy phase oscillators.
Numerical simulations to validate theoretical models.
Experimental analysis of concurrent cell population phases.
In situ entrainment experiments to assess external force coupling.

Main Results:

Theoretical and simulation results distinguished coupling effects from noise.
Experimental evaluation revealed a negligible intercellular coupling strength.
Entrainment experiments confirmed detection of external force coupling and mean phase dynamics.

Conclusions:

Cyanobacterial clock stability is an intrinsic property of the biochemical network.
Intercellular communication does not significantly contribute to clock resilience.
The cyanobacterial circadian oscillator exhibits inherent noise resistance.