Mechanism of the myosin catalyzed hydrolysis of ATP as rationalized by molecular modeling

Bella L Grigorenko1, Alexander V Rogov, Igor A Topol

  • 1Department of Chemistry, M. V. Lomonosov Moscow State University, Moscow 119992, Russian Federation.

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The bonds of adenosine triphosphate (ATP) can be broken through the addition of water, releasing one or two phosphate groups in an exergonic process called hydrolysis. This reaction liberates the energy in the bonds for use in the cell—for instance, to synthesize proteins from amino acids.
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