Related Experiment Video
Updated: Jul 15, 2026

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
Published on: September 28, 2015
[Effects of ACE2-Ang 1-7-Mas axis on blood vessel]
Cui-Qing Liu1, Yu Huang, Li-Min Lu
1Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Abstract:
The recent identification of angiotensin-converting enzyme 2 (ACE2) and Mas receptor opened new recognition of renin-angiotensin system (RAS). ACE2, a homologue of angiotensin-converting enzyme (ACE) generates angiotensin 1-7 directly through cleaving angiotensin II, or indirectly through angiotensin I in the body. Ang 1-7 exhibits vasodilatory and antiproliferative effects, and these effects were mainly mediated by Mas receptor. So ACE2-angiotensin1-7- Mas axis was considered a negative regulation in renin angiotensin system (RAS), and its significance has been implicated into hypertension and other cardiovascular diseases. The identification of the axis opens a new potential venue for further study and understanding of RAS.
Related Concept Videos
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Regulation of Angiogenesis and Blood Supply
Antihypertensive Drugs: Direct Renin Inhibitors
Arteries and Arterioles
Mechanism of Angiogenesis

