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Topical bromfenac sodium for long-term management of vernal keratoconjunctivitis
Eiichi Uchio1, Yuki Itoh, Kazuaki Kadonosono
1Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, Japan. euchio@fukuoka-u.ac.jp
Background/Aims:
We evaluated the efficacy and safety of long-term management of patients with vernal keratoconjunctivitis (VKC) with bromfenac sodium eye drops in combination with corticosteroids and anti-allergic eye drops.
Methods:
Twenty-two patients with VKC were randomly assigned to receive two test eye drops, either bromfenac sodium 0.1% (group A) or placebo eye drops (normal saline; group B) for a mean observation period of 20.9 months. Topical corticosteroids and mast cell stabilizers were continued during the observation period.
Results:
The mean 2-year recurrence rate was 90.9% in group A and 11.3% in group B, with a significant difference. No serious side effect was observed in group A.
Conclusion:
These results suggest that bromfenac sodium eye drops can be used as baseline local treatment in patients with VKC.
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