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Updated: Jul 15, 2026
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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
A formal total synthesis of taxol aided by an automated synthesizer
Takayuki Doi1, Shinichiro Fuse, Shigeru Miyamoto
1Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan.
Chemistry, an Asian Journal
|April 19, 2007
Abstract:
A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well-known precursor of taxol.
