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Updated: Jul 15, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
[Survivin expression in ovarian germ cell tumors]
Ru-Tie Yin1, Zhi-Lan Peng, Kai-Xuan Yang
1Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the relationship between the expression of survivin and the development of ovarian germ cell tumors (OGCT).
Methods:
Survivin expressions in normal ovaries (n = 10) and ovarian germ cell tumors (n = 29) were detected with labelled streptavidin biotin method.
Results:
No survivin protein was expressed in normal ovaries. Survivin protein was found in the cytoplasm and/or the nuclear of cells of 58.6% (17/29) of the ovarian germ cell tumor samples (P < 0.05). There was no significant correlations between surviving protein and the pathologic types, stage, lymphonode metastasis, AFP and volume of ascites of the tumors (P > 0.05).
Conclusion:
High expression of survivin protein may trigger the pathogenesis of the ovarian germ cell tumors.
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