Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perlecan--a multifunctional extracellular proteoglycan scaffold.

Mary C Farach-Carson1, Daniel D Carson

  • 1Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA.

Glycobiology
|April 20, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nonlinear rheology of laminin-111-modified hyaluronan hydrogels.

bioRxiv : the preprint server for biology·2026
Same author

Exploring Spike-Dependent and ACE2-Independent SARS-CoV-2 Interactions with Salivary Epithelial Cells in the Absence of ACE2.

Biology·2026
Same author

Assessing Bioactivity and Biointegration of Engineered Salivary Tissue Constructs in a Preclinical Unilateral Fractionated Irradiated Rat Model.

bioRxiv : the preprint server for biology·2026
Same author

Optimizing Primary Human Salivary Stem/Progenitor Cells for Tissue Engineering Applications.

bioRxiv : the preprint server for biology·2026
Same author

Engineering function in lung biology: integrating imaging, regenerative constructs, and functional biodesign.

American journal of physiology. Lung cellular and molecular physiology·2026
Same author

A prognostic matrix gene expression signature defines functional glioblastoma phenotypes and niches.

Communications biology·2026

Perlecan, a key extracellular matrix proteoglycan, dynamically changes expression during embryo implantation and placentation. Its various forms support critical biological functions throughout pregnancy.

Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Extracellular Matrix Biology

Background:

  • Perlecan is a large heparan sulfate proteoglycan crucial for the extracellular matrix.
  • Its expression is dynamic and vital during embryo implantation and placentation.
  • Perlecan mediates cell adhesion, growth factor binding, and apoptosis modulation.

Purpose of the Study:

  • To review changes in perlecan expression during embryo implantation and placentation.
  • To propose a model for perlecan's function as an extracellular scaffold.
  • To discuss the regulation of perlecan expression and activity.

Main Methods:

  • Literature review of perlecan expression during reproduction.
  • Analysis of perlecan's role in embryonic and maternal compartments.

Related Experiment Videos

  • Synthesis of existing data to model perlecan function.

    • Main Results:

    • Perlecan is expressed by embryonic (trophectoderm, trophoblast) and maternal (uterine epithelia, endothelia, decidua) cells.
    • Expression patterns change dynamically, particularly in the developing decidua.
    • Perlecan functions are regulated at multiple levels: transcriptional, splicing, and proteolysis.

    Conclusions:

    • Perlecan acts as an extracellular scaffold protein during implantation and placentation.
    • Distinct functions are supported by full-length perlecan or smaller derived forms.
    • Understanding perlecan's dynamic roles is crucial for reproductive success.