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Hypoxic respiratory failure: etiology and outcomes at one referral center 2000 through 2005

W E Truog1, G Kurth, B Haney

  • 1Children's Mercy Hospitals and Clinics, Department of Pediatrics, Section of Neonatology, Kansas City, MO 64108, USA. wtruog@cmh.edu

Journal of Perinatology : Official Journal of the California Perinatal Association
|April 20, 2007
PubMed

Insights

Term and near-term infants with hypoxic respiratory failure (HRF) have high survival rates. The need for extracorporeal membrane oxygenation (ECMO) and irreversible disorders are rare in these neonates.

Area of Science:

  • Neonatology
  • Pediatric Critical Care

Background:

  • Hypoxic respiratory failure (HRF) is a critical condition in term and near-term infants.
  • Understanding survival rates and treatment needs is crucial for managing HRF.

Purpose of the Study:

  • To determine the overall survival rate in term and near-term infants with HRF.
  • To assess the incidence of extracorporeal membrane oxygenation (ECMO) use.
  • To evaluate the occurrence of irreversible disorders in this population.

Main Methods:

  • Retrospective review of infants (>=36-week gestation) admitted within 72 hours of age from 2000-2005.
  • Calculation of the highest oxygen index (OI) to assess respiratory severity.
  • Documentation of infant outcomes, including mortality and need for ECMO.

Main Results:

  • 315 infants with primary HRF diagnosis were identified from 630 reviewed.
  • Overall mortality was low (4 deaths).
  • 32 infants received ECMO; all deaths occurred in this subgroup, linked to pulmonary malformations or septic shock.

Conclusions:

  • Term and near-term infants with isolated HRF demonstrate a high likelihood of survival.
  • The incidence of severe pulmonary disorders requiring advanced support like inhaled nitric oxide or ECMO is low.
Abstract

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