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Inflammatory myofibroblastic tumor of the bladder in children: what can be expected?
1Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, Hong Kong. chhouben@web.de
Insights
Inflammatory myofibroblastic tumor (IMT) of the bladder is rare in children and mimics sarcoma. Conservative surgery is the preferred treatment, with no observed recurrences in a 1.5-year follow-up.
Area of Science:
- Pediatric Oncology
- Uropathology
- Surgical Oncology
Background:
- Inflammatory myofibroblastic tumor (IMT) of the bladder is an uncommon neoplastic condition with unknown potential.
- In children, IMT often presents idiopatically, clinically and radiologically resembling sarcoma.
- Distinguishing IMT from sarcoma is critical for appropriate management.
Observation:
- A case study of a 10-year-old girl with bladder IMT is presented.
- Histological and immunohistochemical features are detailed for differential diagnosis.
- A meta-analysis identified 35 pediatric bladder IMT cases from the literature.
Findings:
- Conservative surgical resection is the recommended treatment strategy for pediatric bladder IMT.
- The meta-analysis revealed no evidence of recurrence or metastasis.
- The median follow-up duration was 1.5 years.
Implications:
- Conservative surgery offers a favorable prognosis for pediatric bladder IMT.
- Accurate histological and immunohistochemical analysis is crucial for differentiating IMT from pediatric bladder sarcomas.
- This study supports conservative management as the optimal approach for this rare pediatric tumor.
Abstract:
Inflammatory myofibroblastic tumor of the bladder is an uncommon condition of unknown neoplastic potential. In adults the tumor is seen in association with instrumentation of the lower genitourinary tract, while in children it appears to run an idiopathic course. Its clinical and radiological presentation in children resembles sarcoma. The case of a 10-year-old girl with inflammatory myofibroblastic tumor is presented, outlining the histological and immunhistochemical features to allow differentiation between sarcomas, the most important differential diagnosis. An outcome meta-analysis of the literature identified 35 cases of inflammatory myofibroblastic tumor in the bladder of children. Conservative surgery is the strategy of choice. There is no evidence of recurrence or metastasis at a median follow up of 1.5 years.
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