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Updated: Jul 15, 2026
09:04
Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
Published on: November 19, 2019
Skin grafting for venous leg ulcers
The Cochrane Database of Systematic Reviews
|April 20, 2007
Summary
Bilayer artificial skin, combined with compression, significantly improves venous leg ulcer healing. More research is needed to confirm if other skin grafts offer similar benefits for chronic wounds.
Area of Science:
- Dermatology
- Wound Healing
- Regenerative Medicine
Background:
- Venous leg ulceration is a chronic, recurring condition affecting up to 1% of adults.
- Standard treatments include dressings and compression, but healing can be prolonged.
- Skin grafts, including autografts, allografts, and xenografts, are explored for recalcitrant ulcers.
Purpose of the Study:
- To evaluate the effectiveness of various skin grafting techniques in treating venous leg ulcers.
Main Methods:
- A systematic review of randomized controlled trials (RCTs) was conducted.
- Searches included the Cochrane Wounds Group Specialised Register and the Cochrane Central Register of Controlled Trials.
- Data extraction and quality assessment were performed independently by two reviewers.
Main Results:
- Fifteen trials with 768 participants were included, mostly of low methodological quality.
- Bilayer artificial skin, used with compression bandaging, showed a significantly higher proportion of ulcers healing compared to dressings alone.
- Insufficient evidence exists to determine the efficacy of other skin graft types for venous leg ulcers.
Conclusions:
- Bilayer artificial skin, alongside compression, enhances venous ulcer healing rates.
- Further research is required to ascertain the benefits of other skin graft modalities in venous ulcer treatment.
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