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Related Concept Videos

Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...

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Related Experiment Video

Updated: Jul 15, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Dan Shen agents for acute ischaemic stroke.

B Wu, M Liu, S Zhang

    The Cochrane Database of Systematic Reviews
    |April 20, 2007
    PubMed
    Summary

    Dan Shen herbal medicine shows promise for acute ischemic stroke by improving neurological deficits. However, due to poor study quality, more research is needed to confirm these effects.

    Area of Science:

    • Traditional Chinese Medicine
    • Neurology
    • Pharmacology

    Background:

    • Dan Shen, a herbal medicine, is utilized in China for acute ischemic stroke based on experimental data suggesting improved cerebral microcirculation.
    • Its widespread use necessitates a rigorous assessment of its efficacy and safety.

    Purpose of the Study:

    • To systematically evaluate the effects of Dan Shen agents in patients diagnosed with acute ischemic stroke.

    Main Methods:

    • A comprehensive literature search was conducted across multiple databases (Cochrane, MEDLINE, EMBASE, etc.) and trial registers up to August 2006.
    • Included were randomized or quasi-randomized controlled trials comparing Dan Shen agents with placebo or open controls for acute ischemic stroke.
    • Data extraction and quality assessment were performed independently by two review authors.

    Related Experiment Videos

    Last Updated: Jul 15, 2026

    Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
    09:21

    Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

    Published on: January 18, 2018

    Main Results:

    • Six trials with 494 patients were included; three trials require further assessment.
    • Dan Shen agents demonstrated a significant increase in patients with improved neurological deficits (Peto OR 3.02, 95% CI 1.73 to 5.26).
    • Limited data on deaths, dependent patients, and adverse events were reported; quality of life was not assessed.

    Conclusions:

    • The included studies exhibited poor methodological quality, precluding reliable conclusions.
    • Further high-quality randomized controlled trials are essential to validate the findings on Dan Shen for acute ischemic stroke treatment.