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Updated: Jul 15, 2026

In vitro Electroporation of the Lower Rhombic Lip of Midgestation Mouse Embryos
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[Expression of RAG-1 in brain during mouse development].

Jian-Gang Sun1, Shu Han, Hua Ji

  • 1Department of Anatomy, College of Medicine, Zhejiang University, Hangzhou 310058, China.

Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences
|April 20, 2007
PubMed
Summary

Recombination activating gene-1 (RAG-1) expression is present and increases in the developing mouse brain from embryonic day 11 to birth. This RAG-1 expression is higher in embryonic brains than adult brains, potentially linked to neuron development.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Context:

  • The expression patterns of key genes during embryonic development are crucial for understanding neural circuit formation.
  • Recombination activating gene-1 (RAG-1) is primarily known for its role in V(D)J recombination in lymphocytes.
  • Its presence and function in the central nervous system are less understood.

Purpose:

  • To investigate the spatiotemporal expression of RAG-1 in the developing mouse brain.
  • To determine the localization of RAG-1 within specific brain regions during embryonic and early postnatal stages.

Summary:

  • RAG-1 expression was detected in the mouse brain from embryonic day 11 (E11) through postnatal day 0 (P0).
  • Expression levels increased steadily from E11 to E19, with peak levels observed in embryonic stages compared to adults.

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  • Immunohistochemistry revealed RAG-1 localization in various brain regions including the amygdala, hypothalamus, thalamus, and hippocampus, as well as developing zones of the telencephalic vesicle (VZ, IZ, SVZ, CP, SP).

    • Impact:

    • This study reveals a novel expression pattern of RAG-1 in the developing mammalian brain.
    • The findings suggest a potential role for RAG-1 beyond adaptive immunity, possibly in neuronal development or differentiation.
    • Further research could elucidate the specific functions of RAG-1 in neurogenesis and brain maturation.