Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Canine ocular histiocytic sarcoma.

Carolina Naranjo1, Richard R Dubielzig, Kristen R Friedrichs

  • 1Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain.

Veterinary Ophthalmology
|April 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of Lupus Erythematosus Cells and Ragocytes in Peripheral Blood from a Dog with Systemic Lupus Erythematosus.

Veterinary clinical pathology·2026
Same author

Infection with the Neorickettsial Organism Stellantchasmus falcatus Agent in an Arctic Fox (Vulpes lagopus).

Veterinary clinical pathology·2026
Same author

Diagnostic value of iris biopsies for the assessment of iris pigment changes and diffuse iris melanoma (DIM) in cats: A descriptive histopathological study.

Veterinary pathology·2025
Same author

Sialolith in a minor salivary gland of an 8-year-old European domestic shorthair cat: a case report.

Veterinary research communications·2025
Same author

Canine Protothecosis; Ocular Findings, Diagnosis, Treatment and Outcome in 8 Dogs.

Veterinary ophthalmology·2025
Same author

Histopathologic and ultrastructural features of the choriocapillaris in dogs with sudden acquired retinal degeneration syndrome and progressive retinal atrophy.

Veterinary pathology·2025
Same journal

Lateral Continuous Blepharo-Canthoplasty: A Combination of Hotz-Celsus and Lateral Canthus Wedge Resection for the Correction of Entropion and Macroblepharon in Cats (58 Eyes).

Veterinary ophthalmology·2026
Same journal

Deep Feature-Based Normality Modeling for Automated Out-Of-Distribution Detection in Sheep Retinal Fundus Images.

Veterinary ophthalmology·2026
Same journal

Ocular Manifestations in Dogs With Facial Nerve Dysfunction.

Veterinary ophthalmology·2026
Same journal

Stent-Assisted Surgical Creation of a Ductal Drainage Tract in the Third Eyelid Gland for Treatment of Postoperative Lacrimal Cyst of the Nictitating Membrane in a Dog.

Veterinary ophthalmology·2026
Same journal

Evaluation of Rose-Bengal Photodynamic Antimicrobial Therapy for Refractory Infectious Keratitis in Dogs and Cats (22 Cases).

Veterinary ophthalmology·2026
Same journal

Clinical Features and Surgical Outcomes of Cats With Presumed Primary Lens Instability: A Retrospective Study of 34 Cases (2018-2022).

Veterinary ophthalmology·2026
See all related articles

Histiocytic sarcoma (HS) in dogs often presents as intraocular masses, particularly in Rottweilers and Retrievers. Early diagnosis and differentiation from melanoma are crucial due to the poor prognosis associated with ocular HS.

Area of Science:

  • Veterinary Pathology
  • Ophthalmology
  • Canine Oncology

Background:

  • Histiocytic sarcoma (HS) is an aggressive malignancy in dogs.
  • Ocular involvement of HS can be challenging to diagnose and differentiate from other intraocular tumors.

Purpose of the Study:

  • To characterize ocular histiocytic sarcoma (HS) in dogs.
  • To identify diagnostic markers and prognostic indicators for canine ocular HS.

Main Methods:

  • Retrospective analysis of 26 canine HS cases from the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) database.
  • Histopathological review, immunohistochemistry (Melan-A, CD18, S-100), and ferric iron staining.
  • Clinical data collection including breed, age, gender, and follow-up information.

Related Experiment Videos

Main Results:

  • Rottweilers and Retriever breeds were most commonly affected.
  • Immunohistochemistry confirmed HS with CD18 positivity and Melan-A negativity.
  • Most dogs with follow-up information died due to tumor-related causes, indicating a poor prognosis.

Conclusions:

  • Ocular HS should be included in the differential diagnosis for intraocular masses in dogs, especially certain breeds.
  • CD18 positivity and Melan-A negativity are key discriminators for HS, distinguishing it from melanoma.
  • Ocular HS is often a manifestation of systemic disease, even when first detected in the eye.