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Updated: Jul 15, 2026

RNAi Screening to Identify Postembryonic Phenotypes in C. elegans
09:40

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Published on: February 13, 2012

Novel insights into RNAi off-target effects using C. elegans paralogs

Jean-François Rual1, Niels Klitgord, Guillaume Achaz

  • 1Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. JRUAL@PARTNERS.ORG

BMC Genomics
|April 21, 2007
PubMed
Summary

RNA interference (RNAi) is a powerful gene silencing tool, but off-target effects can occur. This study identifies sequence similarity thresholds to minimize unintended gene silencing in RNAi experiments.

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