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[Risk factors for coronary artery disease stimulate urokinase receptor expression on monocytes]

Wei Chen1, Lian-feng Chen, Wen-ling Zhu

  • 1Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|April 21, 2007
PubMed

Insights

Coronary artery disease risk factors like dyslipidemia and obesity significantly increase urokinase receptor (uPAR) expression on monocytes. This finding highlights uPAR as a potential biomarker for cardiovascular disease risk.

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Molecular Biology

Context:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • Monocytes play a crucial role in the inflammatory processes underlying atherosclerosis.
  • Urokinase receptor (uPAR) is implicated in cell adhesion, migration, and matrix degradation, processes relevant to atherogenesis.

Purpose:

  • To investigate the association between common coronary artery disease (CAD) risk factors and the expression of urokinase receptor (uPAR) on monocytes.
  • To quantify uPAR expression levels in monocytes across different combinations of CAD risk factors.

Summary:

  • A study of 106 patients with CAD risk factors (hypertension, dyslipidemia, obesity) and 17 healthy controls measured monocyte uPAR expression via flow cytometry.
  • Elevated uPAR expression was observed in patients with dyslipidemia and obesity, particularly when these factors were combined.
  • uPAR expression showed a significant correlation with fasting blood glucose in the dyslipidemia group.

Impact:

  • Findings suggest that dyslipidemia and obesity contribute to increased uPAR expression on monocytes in patients with CAD risk factors.
  • Elevated monocyte uPAR may serve as a potential biomarker for assessing cardiovascular disease risk.
  • Further research into the role of uPAR in CAD pathogenesis could reveal novel therapeutic targets.
Abstract

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