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[Tuberculosis after organ transplantation: clinical analysis and literature review]
Wei Wang1, An-sheng Wang, Zhong-yuan Wang
1Research Institute of Tuberculosis of Secondary Affiliated Hospital, PLA General Hospital, Beijing 100091, China.
Objective:
To describe the clinical features, diagnosis and treatment of tuberculosis after organ transplantation.
Method:
The clinical data of 25 cases of tuberculosis after organ transplantation were retrospectively analyzed.
Results:
Sixty-eight percent of the patients presented only mild symptoms. Fever, cough, malaise and chest tightness were among the most common manifestations. Pulmonary tuberculosis, pleurisy, miliary lesions, lymph node disease, and kidney tuberculosis were common. Involvement of two organs were present in 72% (18/25) of the patients. Radiology showed soft lesions, miliary nodules, pleural effusion, hilar and mediastinal lymphadenopathy. Bacteriology and histology were used to confirm the diagnosis in most cases. The average time from presentation to diagnosis was 38 d. The effective rate of therapy was 76% (19/25).
Conclusion:
More attention should be paid to tuberculosis after organ transplantation and immunosuppression. Prompt diagnosis and treatment are important measures to reduce the mortality.
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