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A pilot quality-of-life instrument for acne rosacea
Kimberly Nicholson1, Liana Abramova, Mary-Margaret Chren
1Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Background:
No rosacea-specific quality-of-life (QOL) instrument exists.
Objective:
We sought to develop a validated, reliable rosacea-specific instrument.
Methods:
From 6 in-depth interviews, we composed 21 rosacea-specific items. These items and Skindex-29 were administered in a validation cohort (n = 59). Internal consistency reliability and reproducibility were measured with Cronbach's coefficient alpha and intraclass correlation coefficient, respectively. Responsiveness was assessed comparing baseline with 4- to 6-month responses. Construct validity was assessed with principal axes factor analyses. Discriminant validity was examined with an additional 38 patients comparing differences in responsiveness between the rosacea-specific QOL instrument and Skindex.
Results:
Reliability was high (Cronbach's alpha: 0.82-0.97, intraclass correlation coefficient: 0.70-0.95). The rosacea-specific QOL instrument showed preliminary responsiveness for patients with improved disease (P
Limitations:
Potential selection bias and lack of generalizability was a limitation.
Conclusions:
The rosacea-specific QOL instrument, RosaQoL, appears to be a reliable and valid QOL instrument and shows preliminary responsiveness for patients with improving rosacea.
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