Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Appendicitis

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...

Appendicitis-I: Introduction

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...

Appendicitis-II: Diagnostic Studies and Management

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.

Circulation. Genomic and precision medicine·2019

Same author

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.

Circulation research·2016

Same author

Endovascular Aneurysm Repair Increases Aortic Arterial Stiffness When Compared to Open Repair of Abdominal Aortic Aneurysms.

Vascular and endovascular surgery·2016

Same author

Reply.

The Annals of thoracic surgery·2016

Same author

The implications of different criteria for grading carotid artery stenosis by duplex ultrasound.

Journal of clinical ultrasound : JCU·2015

Same author

Screening for Peripheral Arterial Disease and Carotid Artery Disease in Patients With Abdominal Aortic Aneurysm.

Angiology·2015

Search research articles

Related Experiment Video

Updated: Jul 15, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Malignant neoplasms of the appendix.

Mark E O'Donnell¹, Stephen A Badger, Garth C Beattie

¹Department of Surgery, Antrim Area Hospital, Northern Ireland, UK. modonnell904@hotmail.com

International Journal of Colorectal Disease

|April 21, 2007

Summary

Malignant appendiceal neoplasms are rare and difficult to diagnose pre-operatively. Right hemicolectomy is recommended for most, except small, low-risk carcinoid tumors.

More Related Videos

Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors

Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors

Published on: December 20, 2024

Related Experiment Videos

Last Updated: Jul 15, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors

Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors

Published on: December 20, 2024

Area of Science:

Gastroenterology
Surgical Oncology
Pathology

Background:

Appendiceal neoplasms are rare and challenging to diagnose pre-operatively.
This study reviews a 10-year experience with appendiceal lesions, including epidemiology, pathology, and treatment.
Appendiceal neoplasms were first described in 1882.

Purpose of the Study:

To present a 10-year experience with appendiceal neoplasms.
To review current epidemiology, pathology, and treatment modalities for appendiceal neoplasms.
To identify optimal treatment strategies for malignant appendiceal neoplasms.

Main Methods:

Retrospective histopathological review of appendicectomy specimens (April 1994 - December 2003).
Analysis of patient demographics, operative details, histopathology, and clinical outcomes.
Literature search of PubMed using keywords: appendix, tumour, neoplasm, malignancy.

Main Results:

Twenty-two malignant appendiceal neoplasms identified: 11 carcinoid-type, 8 adenocarcinomas, 3 lymphomas.
Mean follow-up was 41 months; 14 patients survived.
Classical carcinoid tumors (CCT) showed better outcomes than goblet cell carcinoid, adenocarcinoma, and lymphoma.

Conclusions:

Right hemicolectomy is the recommended treatment for most malignant appendiceal neoplasms.
Exceptions include small CCT (<2 cm, low proliferative index, no extension).
Adjuvant therapy should be considered post-oncological assessment.